Acute tubulointerstitial nephritis in Chile: An epidemiological study of hospital discharges over a decade of data (2013–2023)
Acute tubulointerstitial nephritis in Chile: An epidemiological study of hospital discharges over a decade of data (2013–2023)
DOI:
https://doi.org/10.56754/0718-9958.2025.272Keywords:
Tubulointerstitial Nephritis, Epidemiology, Hospitalization, Chile, Internal MedicineAbstract
Introduction: Acute tubulointerstitial nephritis (ATIN) is a significant cause of acute kidney injury, often associated with drug use. In Chile, epidemiological data on this condition are limited. The aim of this study was to analyze hospital discharges due to ATIN between 2013 and 2023.
Materials and Methods: This was an observational, cross-sectional, and descriptive study. Data were obtained from the Department of Health Statistics and Information (DEIS) and the 2017 Census by the National Institute of Statistics (INE). Hospital discharges coded as ICD-10 N10 (“acute tubulointerstitial nephritis”) were selected, and hospital discharge rates (HDR) per 100,000 inhabitants were calculated. Variables were analyzed using descriptive statistics with Microsoft Excel and STATA version 16. Ethical committee approval was not required.
Results: A total of 261,059 hospital discharges due to ATIN were recorded. The HDR showed a significant decreasing trend, with an average annual reduction of 3.09 cases per 100,000 inhabitants. The highest rates were observed among women and individuals over 80 years old. The Biobío region had the highest HDR, while Arica and Parinacota had the lowest. The average hospital stay was 7.52 days, longer in women.
Discussion: The decline in HDR may reflect improved diagnosis or shifts in hospitalization patterns. The higher incidence among women and older adults aligns with the literature and may be linked to immunological factors and comorbidities. Regional differences and prolonged hospital stays in women highlight the need for improved diagnostic protocols and treatment strategies.
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