Efectos del Ozono en la Regeneración Nerviosa en Ratas. Una Revisión Sistemática.

Autores/as

  • Abdías Cofré Morales Universidad de la Frontera
  • Gabriela Cofré Morales
  • Elías Figueroa Villalobos

Palabras clave:

ozono, metilprednisolona, regeneración nerviosa, agentes neuroprotectores

Resumen

ANTECEDENTES: Agentes antioxidantes como el ozono se han utilizado previamente para tratar lesiones nerviosas. Este, en particular, presenta potencial como terapia neuroregenerativa no invasiva debido a su mecanismo de acción. Sin embargo, existen pocos estudios experimentales sobre ozonoterapia y su efecto sobre regeneración nerviosa periférica.

OBJETIVO: Evaluar los efectos de la ozonoterapia (TO) sobre lesiones nerviosas en ratas.

MÉTODO: Para esta revisión sistemática, se consideraron estudios en inglés publicados entre los años 2015 y el 15 de mayo del 2020 con las palabras clave Ozone AND "nerve regeneration”, obtenidos de bases de datos como: Medline (Pubmed), SCOPUS, Web of Science, EMBASE, Clinical Key y Journal of Neurosurgery. La calidad metodológica se evaluó mediante la pauta ARRIVE.

RESULTADOS: De un total de 38 resultados, se incluyeron 7 artículos de acuerdo a los criterios de inclusión. Estos comprenden una cantidad de sujetos de prueba entre 14 y 100 ratas, en donde evaluaron los efectos del ozono en la regeneración nerviosa dentro de un periodo de 7 y 90 días. Los siete estudios arrojaron resultados positivos sobre el tratamiento de lesiones nerviosas con ozono, dos estudios indicaron resultados superiores al utilizar ozono y metilprednisolona combinados.

DISCUSIÓN: Si bien la evidencia recabada fue limitada, la TO demostró capacidades neuroprotectoras y promotoras de regeneración nerviosa al contribuir con la creación de un microambiente favorable para este proceso, capeando los efectos del estrés oxidativo sobre el tejido. La TO complementada con metilprednisolona fue superior a la TO por sí sola, observándose una mayor respuesta antiinflamatoria y antioxidante, con menor índice de degeneración. Esto sugiere un posible potenciamiento de las cualidades neuroprotectoras de ambos tratamientos. Estos hallazgos indican la posibilidad de desarrollar terapias de regeneración nerviosa basadas en ozono en el futuro.

 

 

Citas

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2021-05-07

Cómo citar

1.
Cofré Morales A, Cofré Morales G, Figueroa Villalobos E. Efectos del Ozono en la Regeneración Nerviosa en Ratas. Una Revisión Sistemática. . Rev Estud Med Sur [Internet]. 7 de mayo de 2021 [citado 27 de enero de 2022];9(1). Disponible en: http://rems.ufro.cl/index.php/rems/article/view/120